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探讨非小细胞肺癌淋巴结清扫程度的主要临床研究
Major clinical studies of the extent of lymph node dissection for non-small cell lung cancer
| Author, year, country | Study type | Number of patient | Outcome | Results | Prognostic relevance |
| RS: retrospective study; DFS: disease free survival; RCTs: randomized controlled trials; CMLND: complete mediastinal lymph node dissection; SLND: selective lymph node dissection; MLNS: mediastinal lymph node sampling. | |||||
| Ishiguro et al, 2010, Japan[54] | RS | 772 | 5-year survival | SLND=76% CMLND=71.9% |
No significance (P=0.29) |
| Darling et al, 2011 USA[63] | RCTs | 1, 111 | 5-year DFS | MLNS=69.0% CMLND=68.0% |
No significance (P=0.92) |
| Wu et al, 2001, China[61] | RCTs | 532 | 5-year survival | MLNS=57.5% CMLND=82.2% |
Better survival (P=0.01) |
| Lardinois et al, 2005, Switzerland[62] | RCTs | 100 | Median DFS | MLNS=44.8 month CMLND=60.2 month |
Better DFS (P < 0.03) |
| Okada et al, 2006, Japan[55] | RCTs | 377 | 5-year survival 5-year DFS |
SLND=83.2% CMLND=79.2% SLND=76.4% CMLND=73.4 |
No significance (P=0.37) No significance (P=0.06) |
| Ma et al, 2013, China[66] | RCTs | 96 | 5-year survival 5-year DFS |
SLND=70.9% CMLND=65.5% SLND=64.0% CMLND=60.0% |
No significance No significance |
| Ma et al, 2008, China[53] | RCTs | 105 | 2 cm < T < 3 cm 5-year survival 5-year DFS T≤2 cm 5-year survival 5-year DFS |
MLNS=55.8% SLND=81.6% MLNS=52.5% SLND=77.9% |
Better survival (P=0.04) Better survival (P=0.03) No significance No significance |
| Sugi et al, 1998, Japan[64] | RCTs | 115 | 5-year survival | MLNS=84% CMLND=81% |
No significance |
| Doddali et al, 2005, France[67] | RS | 465 | 5-year survival | MLNS=59.1% CMLND=64.7% |
No significance (P=0.11) |