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. 2018 Jun 7;9:251. doi: 10.3389/fpsyt.2018.00251

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Copyright © 2018 Hayman and Fernandez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ADHD candidate gene network interaction analysis. Using the GeNets network analysis tool (https://apps.broadinstitute.org/genets), we mapped all 105 ADHD candidate genes obtained from the literature (see Supplementary Table S1) onto the InWeb3 meta-network to determine whether they are functionally connected. The density of the mapped network (density = number of edges/number of possible edges) was greater than 95% of randomly sampled gene sets, indicating that the network is significantly more connected than random (p < 2.3E-03). In the network, node (gene) size is proportional to the number of connections. The color is assigned by community, defined as a gene set that is more connected to one another than to another group of genes. Results from this analysis are available in interactive form here: https://www.broadinstitute.org/genets#/computations/5a5d08f9a81b0d6eff609b4b.