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. 2018 Jun 7;9:662. doi: 10.3389/fphys.2018.00662

FIGURE 1.

FIGURE 1

Effects of histidine on the cognitive dysfunctions induced by hypoperfusion. (A) The frequency of correct entrance was increased significantly after histidine administration (n = 6, p < 0.05 compared with Hypoperfusion group). (B) The frequency of wrong entrance was decreased significantly after histidine administration (n = 6, p < 0.05 compared with Hypoperfusion group). (C) The escape latencies of reaching the platform in Morris water maze showed no significant changes among the three groups (n = 6). (D) The frequency of crossing target was decreased significantly in Hypoperfusion group (n = 6, p < 0.05 compared with Sham operation group). Histidine promoted the recovery of the decreased frequency after hypoperfusion slightly without significant difference.