Figure 1.

p62-mediated selective autophagy. p62 interacts with ubiquitinated proteins through its C-terminal ubiquitin-associated (UBA) domain, and forms aggregates through its N-terminal Phox and Bem1 domain. The resulting protein aggregates are tethered to the autophagosome by direct interaction of p62 and light chain 3 localized on the isolation membrane. The isolation membrane elongates and sequesters p62 and ubiquitin into the autophagosome. The autophagosome fuses with lysosome to form an autolysosome.