1.
231例EGFR突变的患者的一般特征
Baseline characteristics of patients with EGFR common mutation (n=231)
| Variables | All (n=231) | First line (n=134) | Second line and above (n=97) | P |
| ECOG: Eastern Cooperative Oncology Group; EGFR: epithelial growth factor receptor. | ||||
| Gender | 0.686 | |||
| Male | 106 | 63 (47.0%) | 43 (44.3%) | |
| Female | 125 | 71 (53.0%) | 54 (55.7%) | |
| Age (yr) | 0.057 | |||
| < 65 | 148 | 79 (59.0%) | 69 (71.1%) | |
| > 65 | 83 | 55 (41.0%) | 28 (28.9%) | |
| Smoking characteristics | 0.611 | |||
| Yes | 72 | 40 (29.9%) | 32 (33.0%) | |
| No | 159 | 94 (70.1%) | 65 (67.0%) | |
| Stage | 0.981 | |||
| Ⅲb | 12 | 7 (5.2%) | 5 (5.2%) | |
| Ⅳ | 219 | 127 (94.8%) | 92 (94.8%) | |
| Histology | 0.394 | |||
| Adenocarcinoma | 221 | 130 (97.0%) | 91 (93.8%) | |
| Non-adenocarcinoma | 10 | 4 (3.0%) | 6 (6.2%) | |
| Brain metastasis | 0.813 | |||
| Yes | 59 | 35 (26.1%) | 24 (24.7%) | |
| No | 172 | 99 (73.9%) | 73 (75.3%) | |
| Liver metastasis | 0.944 | |||
| Yes | 17 | 10 (7.5%) | 7 (7.2%) | |
| No | 214 | 124(92.5%) | 90 (92.8%) | |
| Mutation type | 0.234 | |||
| Exon 19 | 139 | 85 (63.4%) | 54 (55.7%) | |
| 21 L858R | 92 | 49 (36.6%) | 43 (44.3%) | |
| ECOG score | 0.016 | |||
| 0-1 | 188 | 102 (76.1%) | 86(81.4%) | |
| > 2 | 43 | 32 (23.9%) | 11 (18.6%) | |