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肺癌组织中RKIP的表达与肺癌临床病理特征的关系

Correlation between the expression of RKIP with the clinicopathological characteristics of lung cancer

Variable	n	RT-PCR	t	P	Western blot	t	P	RKIP+(%)	χ2	P
*F value.
Gender			0.021	0.984		0.149	0.889		0.312	0.576
Male	48	1.217±0.534			0.612±0.106			19 (39.58)
Female	35	1.209±0.378			0.598±0.124			16 (45.71)
Smoking status			0.005	0.996		0.182	0.864		0.690	0.406
Yes	43	1.213±0.326			0.617±0.205			20 (46.51)
No	40	1.208±0.427			0.587±0.198			15 (37.50)
Age (yr）			0.006	0.995		0.035	0.974		1.627	0.202
< 50	43	1.219±0.423			0.629±0.212			21 (48.84)
≥50	40	1.217±0.358			0.623±0.206			14 (35.00)
Diameter (cm）			0.003	0.998		0.009	0.993		0.017	0.898
< 3	42	1.219±0.479			0.621±0.213			18 (42.86)
≥3	41	1.218±0.378			0.619±0.304			17 (41.46)
Histological type			0.017*	0.988		0.017*	0.987		0.535	0.911
Squamous cell carcinoma	32	1.217±0.372			0.623±0.235			15 (46.88)
Adenocarcinoma	40	1.212±0.367			0.620±0.204			16 (40.00)
Adenosquamous cell carcinoma	8	1.213±0.352			0.598±0.305			3 (37.50)
Large-cell carcinoma	3	1.211±0.377			0.618±0.264			1 (33.33)
Differentiation			3.270*	0.031		2.851*	0.046		9.556	0.008
Well	25	1.786±0.224			0.734±0.224			15 (60.00)
Mediate	23	1.162±0.243			0.318±0.117			12 (52.17)
Poor	35	1.101±0.004			0.104±0.005			8 (22.86)
pTNM stage			3.717	0.021		2.869	0.046		4.928	0.026
Ⅰ+Ⅱ	38	1.747±0.213			0.698±0.214			21 (55.26)
Ⅲ+Ⅳ	45	1.102±0.212			0.306±0.101			14 (31.11)
Survival time (yr)			3.222	0.032		2.962	0.041		6.119	0.013
≥2	39	1.885±0.376			0.728±0.225			22 (56.41)
< 2	44	1.148±0.125			0.302±0.107			13 (29.55)
Lympho invasion			3.093	0.036		3.568	0.023		7.442	0.006
No	40	1.989±0.453			0.737±0.175			23 (57.50)
Yes	43	1.153±0.118			0.309±0.112			12 (27.91)