1.

国内外ALK阳性NSCLC诊断指南或共识^{[7, 9-12]}

Domestic and international diagnostic guidelines or consensus for ALK-postive NSCLC^{[7, 9-12]}

Guidelines or consensus	ALK detecting group	Recommend detecting assay
ALK: anaplastic lymphoma kinase; NSCLC: non-small cell lung cancer; EGFR: epidermal growth factor receptor; IHC: immunohistochemistry; FISH: fluorescence in situ hybridization; NCCN: National Comprehensive Cancer Network; RT-PCR: reverse transcription-polymerase chain reaction.
The diagnosis and treatment guideline of chinese patients with egfr gene active mutation and alk fusion gene-positive non-small cell lung cancer (2014 version)[9]	All of NSCLCpatients with adenocarcinoma component	ALK break apart FISH probe method; RT-PCR or IHC by authority; the routine IHC should be used for screening
Chinese expertconsensus of ALK positive diagnosis in nonsmall cell lung cancer[7]	NSCLC patients with potential possibility of ALK fusion gene should be suggest to detect ALK rearrangement	Vysis ALK break apart FISH probe method; RT-PCR; the routine IHC should be used for screening
NCCN clinical practice guidelines in oncology for non-small cell lung cancer 2014 version 3[10]	NSCLC patients with non squamous cell carcinoma, and non smoking patients with Squamous cell carcinoma, or patients with small biopsy specimens or mixed pathologic types	FISH
IASLC atlas of ALK testing in lung cancer[11]	All of NSCLCpatients with adenocarcinoma component; patients with small biopsy specimens; non NSCLC patients with one of the following conditions: young, or mild/not smoking, EGFR mutation negative	Vysis ALK break apart FISH probe method; IHC method that compared with FISH with high consistency should be used for screening
CAP/IASLC/AMP EGFR and ALK detection guideline[12]	All of NSCLCpatients with adenocarcinoma component; NSCLC patients that can not be ruled out adenocarcinoma component	Vysis ALK break apart FISH probe method; IHC method that compared with FISH with high consistency should be used for screening