3.

NVB治疗后Anip973和Anip973/NVB细胞透射电镜图（×10, 000）。A：透射电镜下Anip973移植瘤细胞经NVB治疗后细胞呈现凋亡的形态。细胞体积缩小，微绒毛结构消失，可见部分细胞核仁消失；B：Anip973移植瘤细胞经NVB治疗后染色质凝聚并形成凋亡小体；C：Anip973/NVB细胞移植瘤经NVB治疗后，表面有大量的微绒毛结构，核仁明显较多，胞质内有丰富的细胞器结构；D：Anip973/NVB细胞移植瘤经NVB治疗后高尔基复合体发达，线粒体较小，还可见到微腺管结构。

Morphological changes in apoptosis observed in Anip973 and Anip973/NVB xenografts after treatment with vinorelbine by TEM (×10, 000). A: Anip973 cells after treatment with vinorelbine presented apoptotic characteristics, such as cell shrinkage, loss of microvilli and nucleolus; B: Anip973 cells after treatment with vinorelbine presented chromatin condensation and formation of apoptotic bodies; C: Anip973/NVB xenografts after treatment with vinorelbine, the surface has a lot of microvilli structure, nucleuos increased clearly, there were rich cytoplasmic in the cytoplasm; D: Anip973/NVB xenografts after treatment with vinorelbine, presented developed golgi complexes, mitochondria was small, and micro-tublar structure can be seen.