4.
PD与PR患者T细胞亚群检测结果（Mean±SD, %）
The T lymphocyte subset seperately in PD and PR group (Mean±SD, %)
| T lymph-ocyte subset | Item | pro-CT | The 4th day of CT | The 10th day of CT | The 21th day of CT | F | P |
| △Mauchly's test of sphericity P < 0.05，corrected by Greenhouse-Geisser; *P < 0.05 in multiple comparisons against pro-CT; #t’ test instead when Levene's test showed varience heterogeneity; PD: progressive disease; PR: partial response. | |||||||
| CD3+ | PD | 67.6±8.3 | 69.1±9.7 | 70.4±6.6* | 67.4±8.3 | 3.114 | 0.067 |
| PR | 65.7±12.0 | 67.4±14.4 | 67.9±14.0* | 66.6±10.9 | 2.111△ | 0.142 | |
| Sum | 66.2±11.0 | 67.8±13.1 | 68.6±12.3 | 66.8±10.0 | 3.577△ | 0.034 | |
| t | 0.675 | 0.250 | 0.375 | 0.584 |
F=0.333△※ P=0.738 |
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| P | 0.508 | 0.805 | 0.712 | 0.566 | |||
| CD3+CD4+ | PD | 41.6±7.6 | 44.1±8.2 | 42.0±6.4 | 41.3±6.5 | 0.161 | 0.920 |
| PR | 36.4±12.2 | 43.6±10.0* | 41.9±12.9* | 37.1±6.5 | 4.546 | 0.008 | |
| Sum | 37.8±11.3 | 43.7±9.3 | 41.9±11.4 | 38.2±6.6 | 1.927 | 0.137 | |
| t | 1.139 | 0.088 | 0.004 | 2.034 |
F=0.628※ P=0.600 |
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| P | 0.269 | 0.931 | 0.997 | 0.057 | |||
| CD3+CD8+ | PD | 24.1±8.7 | 26.7±9.8 | 25.6±4.4 | 24.7±8.9 | 0.115 | 0.949 |
| PR | 27.2±7.6 | 20.6±6.7* | 25.2±8.8 | 27.4±7.9 | 3.409△ | 0.047 | |
| Sum | 26.4±7.8 | 22.2±7.9 | 25.3±7.8 | 26.7±7.9 | 0.363 | 0.780 | |
| t | 0.647 | 1.565 | 0.099 | 1.038 |
F=1.500※ P=0.226 |
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| P | 0.525 | 0.136 | 0.922 | 0.313 | |||
| CD4+/CD8+ | PD | 1.4±0.9 | 1.9±1.0 | 1.6±0.7 | 1.9±0.8 | 0.414 | 0.746 |
| PR | 1.4±0.9 | 2.2±1.0 | 1.8±1.1 | 1.3±0.5 | 3.743 | 0.019 | |
| Sum | 1.4±0.9 | 2.1±1.0 | 1.7±1.0 | 1.4±0.6 | 1.650 | 0.189 | |
| t | 0.243 | 0.628 | 0.404 | 2.744 |
F=0.930※ P=0.433 |
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| P | 0.811 | 0.539 | 0.691 | 0.013 | |||
| CD4+CD25+ | PD | 10.8±2.4 | 10.4±1.5 | 10.9±2.5 | 10.1±2.2 | 0.156 | 0.924 |
| PR | 10.7±4.4 | 11.9±4.3 | 10.6±4.8 | 9.8±2.7 | 0.760 | 0.523 | |
| Sum | 10.7±3.9 | 11.5±3.8 | 10.7±4.3 | 9.9±2.5 | 0.334 | 0.801 | |
| t | 0.162 | 1.102# | 0.132 | 0.458 |
F=0.231※ P=0.874 |
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| P | 0.873 | 0.286 | 0.897 | 0.653 | |||
| CD8+CD28+ | PD | 12.7±5.6 | 14.9±6.2 | 18.0±3.4 | 12.8±3.0 | 2.491 | 0.110 |
| PR | 15.1±4.4 | 13.5±3.8 | 13.9±4.8 | 15.8±4.1 | 1.171 | 0.333 | |
| Sum | 14.5±4.7 | 13.9±4.4 | 15.0±4.7 | 15.0±4.0 | 0.912 | 0.442 | |
| t | 1.313 | 0.613 | 1.777 | 1.599 |
F=3.079※ P=0.036 |
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| P | 0.205 | 0.548 | 0.093 | 0.127 | |||
| CD8+CD28- | PD | 13.4±6.5 | 13.1±6.0 | 11.0±3.0 | 11.8±6.5 | 0.211 | 0.887 |
| PR | 17.7±10.0 | 10.2±4.7* | 15.2±7.7 | 19.3±8.3 | 4.905 | 0.005 | |
| Sum | 15.0±4.0 | 10.9±5.1 | 14.1±7.0 | 17.3±8.4 | 1.312 | 0.281 | |
| t | 0.731 | 1.120 | 1.155 | 1.599 |
F=1.710※ P=0.177 |
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| P | 0.474 | 0.278 | 0.264 | 0.040 | |||