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NSCLC中EGFR、c-Cbl及Cbl-b的表达与临床病理特征的关系

Relationship between EGFR, c-Cbl and Cbl-b expression and clinical pathophysicological characteristic of NSCLC

Parameter	n	EGFR		P	c-Cbl		P	Cbl-b		P
		Positive	Rate		Positive	Rate		High expression (%)	Rate
Age (year)				0.593			0.056			0.770
< 60	59	37	62.7%		22	37.3%		22	37.3%
≥60	35	20	57.1%		7	20.0%		12	34.3%
Sex				0.042			0.876			0.215
Male	73	40	54.8%		22	30.1%		24	32.9%
Female	21	17	81.0%		7	33.3%		10	47.6%
Histology				0.969			0.849			0.518
Squamous cell carcinoma	41	25	61.0%		12	29.2%		12	29.3%
Adenocarcinoma	47	28	59.6%		16	34.0%		20	42.6%
Large cell carcinoma	5	3	60.0%		1	20.0%		2	40.0%
Adenosquamous cell	1	1	100.0%		0	0		0	0
carcinomas
Differentiated				0.483			0.189			0.562
Highly&modrately	60	38	63.3%		22	36.6%		23	38.3%
Poorly	34	19	55.9%		7	20.6%		11	32.4%
Tumor size				0.241			0.078			0.408
T1+T2	70	40	57.1%		25	35.7%		27	38.6%
T3+T4	24	17	70.8%		4	16.7%		7	29.2%
Lymph node metastasis				0.821			0.918			0.839
No	40	24	60.0%		13	32.5%		14	35.0%
Yes	54	33	61.1%		16	29.6%		20	37.0%
P-TNM stage				0.632			0.628			0.719
Ⅰ+Ⅱ	53	31	58.5%		18	34.0%		20	37.7%
Ⅲ	41	26	63.4%		11	26.8%		14	34.1%
Smoking history				0.140			0.945			0.227
No	34	24	70.6%		10	29.4%		15	32.4%
Yes	60	33	55.0%		19	31.7%		19	31.7%