1.
111例肺癌患者配对血液和肿瘤组织样本的EGFR突变分析
Analysis of EGFR mutation in paired blood and tumor tissue samples from 107 patients with lung cancer [n (%)]
| Clinical parameter | No. of sample | Blood | Tissue | |||||
| Mutant | Wild type | P | Mutant | Wild type | P | |||
| aComparison of mutation rates in stage Ⅰ, Ⅱ and Ⅲ, Ⅳ; bcomparison of mutation rates in patients with stage Ⅲ and Ⅳ. EGFR: epidermal growth factor receptor. | ||||||||
| Gender | 0.095 | 0.172 | ||||||
| Male | 45 | 21 (46.7) | 24 (53.3) | 32 (71.1) | 13 (28.9) | |||
| Female | 62 | 39 (62.9) | 23 (37.1) | 51 (82.3) | 11 (17.7) | |||
| Age (yr) | 0.913 | 0.181 | ||||||
| < 60 | 54 | 30 (55.6) | 24 (44.4) | 39 (72.2) | 15 (27.8) | |||
| ≥60 | 53 | 30 (56.6) | 23 (43.4) | 44 (83.0) | 9 (17.0) | |||
| Smoking history | 0.988 | 0.791 | ||||||
| Yes | 16 | 9 (56.3) | 7 (43.7) | 12 (75.0) | 4 (25.0) | |||
| No | 91 | 51 (56.0) | 40 (44.0) | 71 (78.0) | 20 (22.0) | |||
| Stages | ||||||||
| I | 2 | 1 (50.0) | 1 (50.0) | 2 (100.0) | 0 | |||
| Ⅱ | 7 | 1 (14.3) | 6 (85.7) | 2 (28.6) | 5 (71.4) | |||
| Ⅲ | 18 | 4 (22.2) | 14 (77.8) | 0.032a | 10 (55.6) | 8 (44.4) | 0.013a | |
| Ⅳ | 80 | 54 (67.5) | 26 (32.5) | 0.000b | 69 (86.3) | 11 (13.7) | 0.003b | |
| Differentiation | 0.262 | 0.165 | ||||||
| High | 34 | 18 (52.9) | 16 (47.1) | 23 (67.6) | 11 (32.4) | |||
| Middle | 19 | 8 (42.1) | 11 (57.9) | 17 (89.5) | 2 (10.5) | |||
| Low | 54 | 34 (63.0) | 20 (37.0) | 43 (79.6) | 11 (20.4) | |||