2.

所有患者的治疗情况

The clinical course of all the patients

	Age (yr)	Gender	Smoking history	Histological type	EGFR mutation	PFS-1stTKIs (month)	Interval of TKIs	The chemotherapy of the interval	KPS	Response	PFS-2ndTKIs (month)	OS-2ndTKIs (month)
Adeno: adenocarcinoma; PR: partial response; SD: stable disease; PD: progressive disease.
1	68	Male	Never	Adeno	-	10.00	10.41	GEM+CBP	-	PR	1.61	23.03
2	55	Male	Never	Adeno	-	21.26	7.82	Pem	-	SD	3.25	22.00
3	49	Male	Current	Adeno	-	22.21	3.00	Pem+DDP	90	SD	8.00	26.71
4	43	Female	Never	Adeno	-	8.77	5.00	TXT+endo	70	/	1.00	6.00
5	37	Female	Never	Adeno	-	14.09	5.42	Pem+DDP	90	PD	8.02	12.48
6	49	Female	Current	Adeno	-	6.00	4.00	PTX+IFO	80	SD	1.00	10.00
7	63	Female	Never	Adeno	-	30.0	4.00	Pem+CBP,	-	SD	Till now	15.70
8	47	Male	Ex-smoker	Adeno	-	18.37	6.31	PTX+NDP	-	PR	5.32	12.35
9	70	Female	Never	Adeno	-	22.00	3.00	PTX+DDP	70	PD	19.00	21.00
10	46	Male	Never	Adeno	-	Cease for rash	9.00	No treatment	-	/	14.00	17.00
11	41	Female	Never	Adeno	-	10.28	4, .60	Pem+DDP	-	SD	3.00	6.37
12	71	Male	Never	Adeno	-	10.35	13.00	Pem+DDP	90	SD	1.00	9.00
13	52	Female	Never	Adeno	-	16.00	10.00	BIBW2992	-	/	5.00	5.00
14	56	Female	Never	Adeno	-	7.59	2.14	PTX+IFO	90	SD	24.80	38.24
15	38	Female	Never	Adeno	-	9.00	23.00	PTX+CBP; TXT	-	PR SD	9.00	9.00
16	74	Male	Never	Adeno	-	Cease for rash	22.00	Chinese medicine		/	13.00	17.00
17	48	Female	Never	Adeno		24.97	23.00	AZD2171		/	Till now	4.47
18	72	Female	Never	Adeno	Exon-19	7.03	4.37	Pem	80	SD	4.30	3.98