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. 2018 Jun 13;9(6):696. doi: 10.1038/s41419-018-0733-4

Fig. 1. P.A shows significant cytotoxicity in NSCLC cells and inhibits EGFR phosphorylation in EGFR mutant cells.

Fig. 1

a The chemical structure of P.A; b–h P.A dose–response curves in NSCLC cell lines and a normal lung fibroblast cell line (CCD19-LU). The results are expressed as the mean ± S.E. (*p < 0.05, **p < 0.01, ***p < 0.001); i–k P.A specifically inhibited the phosphorylation of EGFR tyrosine residue 1173 in EGFR mutant NSCLC cells but had no effect on EGFR phosphorylation in EGFR wild-type NSCLC cells (A549)