Fig. 2. P.A inhibits colony formation and significantly induces apoptosis in NSCLC cells.

a Data are shown as representative photomicrographs from colony formation assays after treatment of three NSCLC cell lines with different concentrations of P.A; b Morphological changes in three NSCLC cell lines after treatment with P.A; c Flow cytometric analysis of apoptosis levels after P.A treatment and statistical analysis results; d–f Statistical results of C (three independent experiments); g–i PARP, Caspase-3, Caspase-7, Caspase-9, and Bax were cleaved and activated by P.A, while Bcl-2 was downregulated and Akt activation was inhibited (*p < 0.05, **p < 0.01, ***p < 0.001)