Fig. 6. P.A suppresses tumor growth in H1975 xenografts.

a Tumor volume was examined by caliper measurements from the beginning of the treatment period (when the tumor reached approximately 100 mm³ in size), n = 7 per group; b Quantification of body weight for each group; c Fluorescence intensity indicating the size of the tumor in vivo; d, e The weight of each tumor; f P.A decreased the phosphorylation of mTOR, EGFR (Tyr 1173 and Tyr 1068) and Akt activated AMPK and increased DR4 expression; g Immunohistochemistry analysis comparing P.A-treated tumor tissue to vehicle-treated tissue (*p < 0.05, **p < 0.01, ***p < 0.001)