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. 2018 Jun 13;7:107. doi: 10.1038/s41426-018-0113-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Eight-week-old female BALB/c mice (n = 6) were anesthetized with isoflurane and infected intranasally with 1, 10, 100, or 1000 pfu of H5N6/GZ14. The mice were monitored for 14 days. a The body weights were measured every other day. The results from each group and each time point are expressed as the mean ± standard deviations (SD). b Survival of infected mice. Mice were euthanized when body weight loss exceeded 25% of the original weight