2.
EGFR与KRAS基因突变亚组分析
Subgroup analysis of EGFR and KRAS mutation status
| Clinical characteristic | n (%) | EGFR gene | P | KRAS gene n=139 (%) | P | ||
| Mutation (%) | Wild type (%) | Mutation (%) | Wild type (%) | ||||
| Gender | 0.228 | > 0.999 | |||||
| Male | 127 (91.4) | 21 (16.5) | 106 (83.5) | 7 (5.5) | 120 (94.5) | ||
| Female | 12 (8.6) | 4 (33.3) | 8 (66.7) | 0 (0) | 12 (100.0) | ||
| Age (yr) | 33-82 (62.30±0.87) | > 0.999 | 0.242 | ||||
| < 65 | 77 (55.4) | 14 (18.2) | 63 (81.8) | 2 (2.6) | 75 (97.4) | ||
| ≥65 | 62 (44.6) | 11 (17.7) | 51 (82.3) | 5 (8.1) | 57 (91.9) | ||
| Smoking history | 0.181 | 0.086 | |||||
| Non-smoker | 27 (19.4) | 8 (29.6) | 19 (70.4) | 3 (11.1) | 24 (88.9) | ||
| Light-smoker | 19 (13.7) | 2 (10.5) | 17 (89.5) | 2 (10.5) | 17 (89.5) | ||
| Smoker | 93 (66.9) | 15 (16.1) | 78 (83.9) | 2 (2.2) | 91 (97.8) | ||
| TNM stage | 0.194 | 0.335 | |||||
| Ⅰ | 25 (18.0) | 3 (12.0) | 22 (88.0) | 1 (4.0) | 24 (96.0) | ||
| Ⅱ | 27 (19.4) | 8 (29.6) | 19 (70.4) | 2 (7.4) | 25 (92.6) | ||
| Ⅲ | 38 (27.3) | 4 (10.5) | 34 (89.5) | 0 (0) | 38 (100.0) | ||
| Ⅳ | 49 (35.3) | 10 (20.4) | 39 (79.6) | 4 (8.2) | 45 (91.8) | ||
| Biopsy type | 0.132 | 0.779 | |||||
| Incisional | 86 (61.9) | 18 (20.9) | 68 (79.1) | 6 (7.0) | 80 (93.0) | ||
| Bronchoscopic | 29 (20.9) | 2 (6.9) | 27 (93.1) | 0 (0) | 29 (100.0) | ||
| Core biopsy | 19 (13.7) | 4 (21.1) | 15 (78.9) | 1 (5.3) | 18 (94.7) | ||
| Localisation | 3 (2.2) | 0 (0) | 3 (100.0) | 0 (0) | 3 (100.0) | ||
| Pleural | 1 (0.7) | 1 (100.0) | 0 (0) | 0 (0) | 1 (100.0) | ||
| Mediastinum | 1 (0.7) | 0 (0) | 1 (100.0) | 0 (0) | 1 (100.0) | ||