2.
XRCC1和XRCC3基因型与NSCLC化疗敏感性的关系
The relationship between XRCC1 and XRCC3 genotypes and chemosensitivity of NSCLC
| Genotype | n (%) | Response to chemotherapy [n (%)] | P | OR | 95%CI | |
| CR+PR | SD+PD | |||||
| CR:complete response; PR:partial response; SD:stable disease; PD:progressive disease; NSCLC:non-small cell lung cancer. | ||||||
| XRCC1 Arg194 Trp | ||||||
| Arg/Arg | 54 (41.5) | 12 (22.2) | 42 (77.8) | - | 1 | - |
| Arg/Trp | 40 (30.8) | 14 (35.0) | 26 (65.0) | 0.171 | 1.885 | 0.756-4.696 |
| Trp/Trp | 36 (27.7) | 18 (50.0) | 18 (50.0) | 0.006 | 3.500 | 1.401-8.744 |
| Arg/Trp+Trp/Trp | 76 (58.5) | 32 (42.1) | 44 (57.9) | 0.018 | 2.545 | 1.159-5.590 |
| XRCC1 Arg399 Gln | ||||||
| Arg/Arg | 66 (50.8) | 30 (45.5) | 36 (54.5) | - | 1 | - |
| Arg/Gln | 54 (41.5) | 14 (25.9) | 40 (74.1) | 0.027 | 0.420 | 0.193-0.914 |
| Gln/Gln | 10 (7.7) | 0 (0) | 10 (100.0) | 0.005 | 0 | 0 |
| Arg/Gln+ Gln/Gln | 64 (49.2) | 14 (21.9) | 50 (78.1) | 0.005 | 0.336 | 0.156-0.722 |
| XRCC3 Thr241 Met | ||||||
| Thr/Thr | 114 (87.7) | 36 (31.6) | 78 (68.4) | - | 1 | - |
| Thr/Met | 16 (12.3) | 8 (50.0) | 8 (50.0) | 0.145 | 2.167 | 0.753-6.232 |