2.

A549/DDP细胞中miR-503对药物敏感性，Rh-123的胞内浓度及细胞凋亡的作用。A：MTS法结果显示与对照组相比，转染pre-miR-503后，细胞对顺铂的敏感性明显增加，数据以Mean±SD表示，n=10，^*表示与对照组相比，P < 0.05；B：流式细胞术结果表明与对照组相比，转染pre-miR-503后，细胞内Rh-123的浓度增加，数据以Mean±SD表示，n=10，^*表示与对照组相比，P < 0.05；C：流式细胞术结果表明与对照组相比，转染pre-miR-503后，细胞凋亡数目增加，数据以Mean±SD表示，n=10，^*表示与对照组相比，P < 0.05。

The effect of miR-503 on drug sensitivity, intracellular level of Rh-123 and apoptosis in A549/DDP cells. A: The MTS assay indicated that the DDP-sensitivity in pre-miR-503 group was significantly increased while compared to the control group. Data was represented as Mean±SD, n=10, bars indicate SD, ^*compared to the control group (P < 0.05); B: The flow cytometry assay results showed that there was an increased intracellular level of Rh-123 in pre-miR-503 group compared with control group. Data was represented as Mean±SD, n=10, bars indicate SD, ^*compared to the control group (P < 0.05); C: The flow cytometry assay results showed that there was an increased apoptosis in pre-miR-503 group compared with control group. Data was represented as Mean±SD, n=10, bars indicate SD, ^*compared to the control group (P < 0.05).