3.

A549/DDP细胞中转染pre-miR-503后，耐药相关基因的蛋白表达水平。Western blot结果显示，与对照组相比，MDR1、MRP1、ERCC1、Survivin和Bcl-2的蛋白水平明显降低，而RhoE的蛋白水平明显增加，α-tubulin为内参。

The expression of different drug-resistance related genes in A549/DDP cells transfected with pre-miR-503. Compared to the control group, the expression of MDR1, MRP1, ERCC1, Survivin and Bcl-2 were dramatically down-regulated while the expression of RhoE was significantly up-regulated in pre-miR-503 group by western blot assay. α-tubulin was used as an internal control.