2.

Kaplan-Meier法单因素生存分析

Univariate survival analysis by Kaplan-Meier method

Parameters	Levels	Overall survival (months) (95%CI)	Chi-Square	P
C: chemotherapy, R: radiotherapy, S: surgery, P: palliative care.
Age	≤60 vs > 60	6.8 (5.3-8.3) vs 8.2 (7.1-9.3)	6.068	0.014
Gender	Male vs Female	8.0 (6.9-9.1) vs 7.1 (5.6-8.6)	0.236	0.627
Histological type	Adenocarcinoma vs Squamous cell vs Adenosquamous vs Small-cell vs Other	7.7 (6.7-8.7) vs 8.0 (3.1-12.9) vs 7.9 (4.5-11.3) vs 8.3 (6.9-9.7) vs 6.4 (1.7-11.1)	1.571	0.814
Differentiation	High vs Moderate vs Low	18.4 (5.6-31.2) vs 10.4 (9.1-11.7) vs 6.9 (5.2-8.6)	3.266	0.195
Clinical stage	Ⅰ vs Ⅱa vs Ⅱb vs Ⅲa vs Ⅲb vs Ⅳ	9.5 (3.2-15.8) vs 7.6 (6.3-8.9) vs 7.9 (3.7-12.1) vs 10.1 (7.2-13.0) vs 6.1 (4.8-7.4) vs 7.4 (6.6-8.2)	10.965	0.052
Metastatic range	Central vs Peripheral	7.6 (6.5-8.7) vs 7.8 (6.4-9.2)	2.536	0.111
ECOG PS	0 vs 1 vs 2 vs 3 vs 4	16.1 (13.7-18.5) vs 11.1 (9.8-12.4) vs 5.2 (4.4-6.0) vs 1.9 (1.5-2.3) vs 0.1	432.761	< 0.001
Metastatic interval	≤6 months vs 6-12 months vs ≥12 months	6.9 (4.7-9.1) vs 5.7 (4.6-6.8) vs 10.3 (7.8-12.8)	8.190	0.017
Metastatic sites	Cerebrum vs Cerebellum vs Other	7.7 (6.9-8.5) vs 9.4 (7.6-11.2) vs 5.2 (0-10.4)	1.432	0.489
Metastatic numbers	Single vs Multiple	9.3 (7.7-10.9) vs 6.8 (5.7-7.9)	10.975	0.001
Treatment methods	C or R vs C and R vs S vs P	3.0 (2.0-4.0) vs 9.0 (7.6-10.4) vs 11.0 (9.7-12.3) vs 1.7 (1.4-2.0)	194.499	< 0.001
Treatment cycles	≤3 cycles vs ≥4 cycles	5.1 (4.6-5.6) vs 13.3 (11.8-14.8)	148.612	< 0.001
Symptoms of brain metastases	Yes vs No	6.8 (5.4-8.2) vs 9.3 (7.6-11.0)	4.939	0.026
Extracranial metastasis	Yes vs No	7.1 (6.3-7.9) vs 10.1 (8.6-11.6)	8.459	0.004
Brain metastases order	First site vs No first site vs Same time	13.3 (8.3-18.3) vs 5.2 (3.5-6.9) vs 6.9 (6.2-7.6)	14.443	0.001