1.
纳入研究的对象的基本特征
Main characteristics of the included studies
| Author | Tumor tissue | Cotrol tissue | Control type | Stage | Method | Region | Time |
| (M+/M-) | (M+/M-) | (Ⅰ/Ⅱ/Ⅲ/Ⅳ/other) | |||||
| MSP: methylation specific PCR; Q-MSP: Quantitative MSP. | |||||||
| Hubers[5] | 31/73 | 3/86 | Sputum | 14/9/24/25/1 | MSP | Netherland | 2015 |
| Zhai[6] | 22/42 | 0/40 | Plasm | 4/2/14/22/- | MSP | China | 2014 |
| Li[7] | 48/56 | 0/56 | Plasm | 15/7/20/14/- | MSP | China | 2014 |
| Tan[8] | 55/200 | 34/200 | Plasm | - | q-MSP | China | 2013 |
| Li[9] | 45/56 | 0/52 | Plasm | 15/7/20/14/- | MSP | China | 2012 |
| Lee[10] | 92/206 | 1/40 | Tissue | 130/76/- | MSP | Korea | 2012 |
| Song[11] | 31/78 | 6/78 | Tissue | 25/33/19/1/- | MSP | China | 2011 |
| Zhang[12] | 58/150 | 0/20 | Tissue | 49/32/48/21/- | MSP | China | 2010 |
| Helmbold[13] | 17/18 | 0/18 | Tissue | - | MSP | Germany | 2009 |
| Lin[14] | 53/124 | 2/26 | Tissue | - | MSP | China | 2009 |
| Liu[15] | 40/60 | 7/60 | Tissue | - | MSP | China | 2008 |
| Brock[16] | 25/50 | 37/104 | Tissue | - | MSP | USA | 2008 |
| Yu[17] | 23/75 | 0/50 | Plasm | 9/18/28/20/- | MSP | China | 2008 |
| Yanagawa[18] | 43/101 | 3/101 | Tissue | 68/7/26/-/- | MSP | Japan | 2007 |
| Wang[19] | 23/75 | 0/15 | Plasm | - | MSP | China | 2007 |
| Hsu HS[20] | 30/63 | 3/36 | Tissue/Plasm | 41/21/1 | MSP | China | 2007 |
| Chen[21] | 44/114 | 4/57 | Tissue | 50/64/- | MSP | China | 2006 |
| Ito[22] | 44/138 | 0/138 | Tissue | - | MSP | Japan | 2005 |
| Fujiwara[23] | 11/91 | 8/100 | Plasm | 53/7/22/9/- | MSP | Japan | 2005 |
| Safar[24] | 19/105 | 2/32 | Tissue | 38/8/32/22/- | MSP | USA | 2005 |
| Choi[25] | 47/116 | 0/116 | Tissue | 68/23/25/-/- | MSP | Korea | 2005 |
| Wang[26] | 46/119 | 4/119 | Tissue | - | MSP | China | 2004 |
| Burbee[27] | 32/107 | 0/104 | Tissue | 60/21/25/-/- | MSP | Sweden | 2001 |