3.
紫杉醇脂质体和紫杉醇脂质体联合奥沙利铂的毒副作用
Toxicities between paclitaxel liposome group and paclitaxel liposome plus oxaliplatin group
| Toxicities | Paclitaxel liposome group (n=35) | Paclitaxel liposome plus oxaliplatin group (n=34) | P | |||||||
| Ⅰ | Ⅱ | Ⅲ | Ⅳ | Ⅰ | Ⅱ | Ⅲ | Ⅳ | |||
| Haematological toxicities | ||||||||||
| Leukocytopenia | 5 | 6 | 4 | 0 | 6 | 4 | 3 | 0 | 0.808 | |
| Thrombocytopenia | 3 | 1 | 0 | 0 | 2 | 2 | 0 | 0 | ＞0.999 | |
| Anemia | 2 | 1 | 0 | 0 | 3 | 2 | 0 | 0 | 0.477 | |
| Nonhaematologicaltoxicies | ||||||||||
| Nausea and vomiting | 5 | 2 | 0 | 0 | 7 | 1 | 0 | 0 | 0.777 | |
| Arthralgia | 4 | 1 | 0 | 0 | 5 | 0 | 0 | 0 | ＞0.999 | |
| Neurotoxicity | 3 | 0 | 0 | 0 | 21 | 12 | 0 | 0 | ＜0.001 | |
| Dysfunction of liver | 4 | 0 | 0 | 0 | 5 | 2 | 0 | 0 | 0.342 | |
| Dysfunction of kidney | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | ＞0.999 | |