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. 2012 Feb 20;15(2):112–116. [Article in Chinese] doi: 10.3779/j.issn.1009-3419.2012.02.09

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文献所用检测EML4-ALK的方法及阳性率

EML4-ALK fusion gene previously reported by the literatures in lung cancer

Author EML4-ALK(%, n/N Area Method
Soda[7] 6.67%(5/75) Japan RT-PCR
Takeuchi[9] 4.35%(11/253) Japan RT-PCR
Jokoji[11] 3.15%(8/254) Japan FISH
Shaw[13] 13.48%(19/141) World FISH
Lin[14] 11.32%(12/106) US FISH,exon array,RT-PCR
Zhang[18] 11.65%(12/103) China RACE-coupled PCR
Takeuchi[19] 6.15%(8/130) Japan iAEP,RT-PCR
Fukuyoshi[20] 0.96%(1/104) Japan RT-PCR
Koivunen[21] 2.62%(8/305) US (138), Korea (167) RT-PCR
Inamura[22] 3.03%(11/363) Japan RT-PCR
Martelli[23] 7.50%(9/120) Italy, Spain RT-PCR
Takahashi[24] 1.60%(5/313) Japan RT-PCR
Wong[25] 4.89%(13/266) China RT-PCR