3.
先证者的一级亲属患癌风险性（以年龄分层）
Risk of cancer in first-degree relatives of Proband stratified by age
| Age cohort | Factors | Case/Control | Crude OR (95%CI) | Adjusted ORa (95%CI) | |
| a: ORs calculated by conditional logistic regression adjusted for sex, lung disease history, smoking status, living environment and occupation expose. | |||||
| < 50 years | Proband’s family history | No | 86/112 | 1.00 | 1.00 |
| Yes | 39/24 | 2.12 (1.18-3.78) | 2.01 (1.08-3.74) | ||
| N of families with | 0 | 86/112 | 1.00 | 1.00 | |
| 1 | 32/23 | 1.81 (0.99-3.32) | 1.71 (0.90-3.28) | ||
| 2+cancers | 7/1 | 9.12 (1.10-75.50) | 8.85 (1.01-77.80) | ||
| ≥50 years | Proband’s family history | No | 346/326 | 1.00 | 1.00 |
| Yes | 162/103 | 1.48 (1.11-1.98) | 1.64 (1.18-2.27) | ||
| N of families with | 0 | 346/326 | 1.00 | 1.00 | |
| 1 | 117/88 | 1.25 (0.91-1.72) | 1.52 (1.07-2.17) | ||
| 2+cancers | 45/15 | 2.83 (1.55-5.17) | 2.21 (1.14-4.28) | ||