3.

115例三线治疗的Ⅲb期/Ⅳ期肺癌患者三线PFS和OS多因素分析

Multivariate analysis of PFS and OS (from the initiation of third-line treatment) for 115 stage Ⅲb/Ⅳ lung cancer patients receiving third-line therapy

Variable	PFS			OS
	HR（95%CI）	P		HR（95%CI）	P
Gender	0.77 (0.50-1.17)	0.222		0.79 (0.50-1.26)	0.324
Age	0.84 (0.53-1.31)	0.441		1.52 (0.91-2.53)	0.107
Stage	0.79 (0.50-1.25)	0.313		0.64 (0.37-1.10)	0.108
Surgical history	0.84 (0.48-1.47)	0.541		1.01 (0.54-1.88)	0.982
Smoking history	1.38 (0.90-2.11)	0.146		1.86 (1.16-2.99)	0.011
Histology	0.86 (0.51-1.47)	0.589		0.91 (0.48-1.70)	0.758
Performance score	2.61 (1.62-4.20)	< 0.001		3.11 (1.91-5.06)	< 0.001
Response to prior treatments	0.74 (0.49-1.11)	0.142		1.61 (1.01-2.57)	0.044
Third-line drug	1.07 (0.83-1.38)	0.593		1.01 (0.76-1.35)	0.948