1.

纳入研究的一般特征

The characteristics of included

Reference	Arm	Treatment schedule and dose	No. of patients	Age (yr)	PS	OS (wk)	1-y SR (%)	ORR (%)
→: dose escalation; PS: performance status; OS: overall survival; 1-y SR: 1-year survival rate; ORR: overall response rate.
Frasci 2001[14] (Lung Cancer)	Traetment	Gemcitabine at 1, 200 mg/m2 on days 1 and 8, every 3 weeks Vinorelbine at 30 mg/m2 on days 1 and 8, every 3 weeks	60	≥70	16	29	30	22
	Control	Vinorelbine at 30 mg/m2 on days 1 and 8, every 3 weeks	60	≥70	13	18	13	15
Gridelli 2003[15] (J Natl Cancer Inst)	Traetment	Gemcitabine at 1, 000 mg/m2 on days 1 and 8, every 3 weeks Vinorelbine at 25 mg/m2 on days 1 and 8, every 3 weeks	232	≥70	44	30	30	21
	Control	Gemcitabine at 1, 200 mg/m2 on days 1 and 8, every 3 weeks	233	≥70	41	28	28	16
	Traetment	Gemcitabine at 1, 000 mg/m2 on days 1 and 8, every 3 weeks Vinorelbine at 25 mg/m2 on days 1 and 8, every 3 weeks	232	≥70	44	30	30	21
	Control	Vinorelbine at 30 mg/m2 on days 1 and 8, every 3 weeks	233	≥70	45	36	38	18
Comella 2004[16] (Br J Cancer)	Traetment	Gemcitabine at 1, 000→1, 200 mg/m2 on days 1 and 8, every 3 weeks Vinorelbine at 25→30 mg/m2 on days 1 and 8, every 3 weeks	68	≥70	21	9.7	32	23
	Control	Gemcitabine at 1, 200→1, 400→1, 600 mg/m2 on days 1 and 8 and 15, every 4 weeks	68	≥70	19	5.1	29	18
	Traetment	Gemcitabine at 1, 000→1, 200 mg/m2 on days 1 and 8, every 3 weeks Vinorelbine at 25→30 mg/m2 on days 1 and 8, every 3 weeks	68	≥70	21	9.7	32	23
	Control	Paclitaxei at 100→120→140 mg/m2 on days 1, 8 and 15, every 4 weeks	63	≥70	22	6.4	25	13
	Traetment	Gemcitabine at 1, 000→1, 200 mg/m2 on days 1 and 8, every 3 weeks Paclitaxei at 80→100 mg/m2 on days 1 and 8, every 3 weeks	65	≥70	15	9.2	44	32
	Control	Gemcitabine at 1, 200→1, 400→1, 600 mg/m2 on days 1, 8 and 15, every 4 weeks	68	≥70	19	5.1	29	18
	Traetment	Gemcitabine at 1, 000→1, 200 mg/m2 on days 1 and 8, every 3 weeks Paclitaxei at 80→100 mg/m2 on days 1 and 8, every 3 weeks	65	≥70	15	9.2	44	32
	Control	Paclitaxei at 100→120→140 mg/m2 on days 1, 8 and 15 every 4 weeks	63	≥70	22	5.1	25	13
Sun Q 2006[17] (Chin J Geriatr)	Traetment	Gemcitabine at 1, 000 mg/m2 on days 1 and 8, every 3 weeks Cisplatin at 20 mg/m2 on days 1 to 3, every 3 weeks	22	≥70	8	9.2	45.5	40.9
	Control	Vinorelbine at 25 mg/m2 on days 1 and 8, every 3 weeks	23	≥70	9	8.8	43.5	34.9
Zhang K 2006[18] (Chin J Clin Oncol)	Traetment	Paclitaxel at 60 mg/m2 on days 1, 8 and 15, every 4 weeks Cisplatin at 30 mg/m2 on days 2 to 4, every 4 weeks	34	≥65	-	9	38.2	55.9
	Control	Paclitaxel at 60 mg/m2 on days 1, 8 and 15, every 4 weeks	30	≥65	-	8	36.7	26.7
	Traetment	Paclitaxel at 60 mg/m2 on days 1, 8 and 15, every 4 weeks Carboplatin at 5 AUC on days 2, every 4 weeks	32	≥65	-	10	43.8	56.3
	Control	Paclitaxel at 60 mg/m2 on days 1, 8 and 15, every 4 weeks	30	≥65	-	8	36.7	26.7
Hainsworth 2007[19] (Cancer)	Traetment	Docetaxel at 30 mg/m2 on days 1, 8 and 15, every 4 weeks Gemcitabine at 800 mg/m2 on days 1 and 8 and 15, every 4 weeks	174	> 65	65	5.5	26	25 (126)
	Control	Docetaxel at 36 mg/m2 on days 1, 8 and 15, every 4 weeks	171	> 65	57	5.1	24	17 (130)
Huang C 2007[20] (J Tianjin Med University)	Traetment Control	Vinorelbine at 25 mg/m2 on days 1 and 5, every 3 weeks Cisplatin at 20 mg/m2 on days 2 to 4, every 3 weeks Vinorelbine at 25 mg/m2 on days 1 and 5, every 3 weeks	28 30	≥70 ≥70	- -	9.3 9.1	46.4 43.3	39.3 30
Chen 2008[21] (Lung Cancer)	Traetment	Vinorelbine at 22.5 mg/m2 on days 1 and 8, every 3 weeks Cisplatin at 50 mg/m2 on days 1, every 3 weeks	34	≥70	16	11.3	47.2	32.4
	Control	Vinorelbine at 25 mg/m2 on days 1 and 8, every 3 weeks	31	≥70	16	12	50.9	16.1
Li PY 2008[22] (J Clin Pulmonary Med)	Traetment	Paclitaxel at 135 mg/m2 on days 1, every 3 weeks Cisplatin at 20 mg/m2 on days 2 to 4, every 3 weeks	29	≥65	-	-	46.4	37.9
	Control	Paclitaxel at 135 mg/m2 on days 1, every 3 weeks	29	≥65	-	-	43.3	31
Jiang JL 2010[23] (Clin J Traditional Med)	Traetment	Paclitaxel at 175 mg/m2 on days 1, every 3 weeks Oxaliplatin at 130 mg/m2 on days 1, every 3 weeks	18	≥70	16	11.4	50	44.4
	Control	Paclitaxel at 175 mg/m2 on days 1, every 3 weeks	20	≥70	16	13.2	44	35
Lou GY 2010[24] (Natl Med J China)	Traetment	Gemcitabine at 1, 000 mg/m2 on days 1 and 8, every 3 weeks Carboplatin at 5 AUC mg/m2 on days 2, every 3 weeks	34	≥70	3	-	32	41
	Control	Gemcitabine at 1, 000 mg/m2 on days 1 and 8, every 3 weeks	34	≥70	3	-	31	38
Quoix 2011[25] (Lancet)	Traetment	Paclitaxei at 90 mg/m2 on day 1, 8 and 15, every 4 weeks Carboplatin at 6 AUC on day 1, every 4 weeks	225	≥70	61	10.3	44.5	27.1
	Control	Gemcitabine at 1, 150 mg/m2 on days 1 and 8, every 3 weeks & Vinorelbine at 25 mg/m2 on days 1 and 8, every 3 weeks	226	≥70	62	6.2	25.4	10.2