3.

含铂双药与单药化疗的3/4级毒副反应

Comparison of Grade 3/4 toxicity between platinum-based doublet arms and single-agent arms in trials

Toxicity	No. of Trials	No. of patients		OR	95%CI	P
		Doublet arms	Single-agent arms
Anemia	4	487	484	2.21	1.19-4.13	0.013
Neutropenia	4	303	306	5.51	3.67-8.27	< 0.001
Thrombocytopenia	7	388	392	5.13	2.48-10.60	< 0.001
Nausea & vomiting	6	354	358	7.48	1.00-55.77	0.050
Neurotoxicity	4	303	306	5.5	1.53-19.83	0.009