2.
SPHK1的阳性表达与患者临床特征的关系
Association of SPHK1 with clinical parameters
| Patients characteristics | SPHK1 expression | χ2 | P* | |
| Low | High# | |||
| #The median expression level was used as the cutoff. Low expression of SPHK1 in 23 patients was classified as values of 2-△△ct below 1.0.High SPHK1 expression in 53 patients was classified as values of 2-△△ct above 1.0. *For analysis of correlation between of SPHK1 levels and clinical features, Chi-square Test were used. Results were considered statistically significant at P＜0.05. | ||||
| All cases (n=76) | 23 | 53 | ||
| Age | 0.042 | 0.838 | ||
| ＜50 | 12 | 29 | ||
| ≥50 | 11 | 24 | ||
| Gender | 0.636 | 0.425 | ||
| Male | 9 | 26 | ||
| Female | 14 | 27 | ||
| Disease stage | 8.224 | 0.004 | ||
| Limited disease (LD) | 16 | 18 | ||
| Extensive-stage disease (ED) | 7 | 35 | ||
| Response to chemotherapy | 11.412 | 0.001 | ||
| Response | 15 | 13 | ||
| Refractory | 8 | 40 | ||
| Survival state (3 mo-38 mo) | 14.993 | ＜0.001 | ||
| Survival | 18 | 16 | ||
| Death | 5 | 37 | ||