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. 2013 Feb 20;16(2):61–66. [Article in Chinese] doi: 10.3779/j.issn.1009-3419.2013.02.01

1.

动物实验基本情况

Basic information about the experiment

Group Dose (mg/kg) Number of mice Frequency position MW (Mean±SD, g) TW
(Mean±SD, g)
T/C (%) TIR P #
B E B E
NS: sterile normal saline; Biw: bis in week; #compared with control group; Perit: Peritumoral injection; CG: control group; EG: endostatin group; BG: bevacizumab group; COG: combining group; MW: mice weight; TW: tumor weight; B: before treatment; E: end of experiments; TIR: tumor inhibition rate; T/C (%) proliferation rate.
CG N.S. 6 6 Perit×16 qd 5.2±1.1 25.7±1.1 0.35±0.06
EG 3 6 6 Perit×16 qd 25.3±1.2 25.8±1.1 0.22±0.10 64.83 38.68 < 0.01
BG 5 6 6 Perit×6 Biw 25.4±1.4 26.0±0.8 0.17±0.07 50.74 52.36 < 0.01
COG 3 6 6 Perit×16 qd 24.4±1.2 25.6±0.4 0.13±0.07 41.30 64.15 < 0.01
5 Perit×6 Biw