3.

3/4级毒性反应的meta分析

Meta-analysis of grade 3/4 toxicities

Toxicities	Quantity (n)	Observation	Control	Heterogeneity analysis		Effects model	RR (95%CI)	Z	P
				I2(%)	P
Low-does bevacizumab (7.5 mg/kg)
Leukopenia	2[3, 6]	142/362	111/359	0	0.771	Fixed	1.27 (1.04-1.55)	2.32	0.020
GI reactions	2[3, 6]	29/362	14/359	0	0.789	Fixed	2.06 (1.11-3.82)	2.28	0.023
Hypertension	2[3, 6]	21/362	6/359	54.3	0.135	Random	1.88 (0.19-18.71)	0.54	0.590
Bleeding events	2[3, 6]	19/362	6/359	3.3	0.309	Fixed	2.75 (1.05-7.21)	2.06	0.039
High-does bevacizumab (15 mg/kg)
Leukopenia	6[3-8]	326/990	219/876	48.8	0.196	Fixed	1.33 (1.18-1.49)	4.10	0.020
Anemia	5[4-8]	95/1, 286	94/1, 235	46.6	0.096	Fixed	0.94 (0.72-1.23)	0.46	0.643
GI reactions	4[3, 5, 6, 8]	41/522	17/459	0	0.889	Fixed	2.26 (1.31-3.89)	2.94	0.003
Proteinuria	3[4, 6, 8]	17/875	0/825	0.8	0.365	Fixed	11.5 (2.38-55.73)	3.03	0.002
Hypertension	6[3-8]	73/948	9/899	0	0.741	Fixed	6.94 (3.59-13.43)	5.79	< 0.001
Bleeding events	5[4-8]	38/948	10/899	0	0.743	Fixed	3.27 (1.67-6.41)	3.45	0.001