3.

预后分析结果

Results of prognostic analysis

	Fourth-line mPFS (mo)	Univariate (Multivariate)	Fourth-line mOS (mo)	Univariate (Multivariate)
mPFS: median progression free survival; mOS: median overall survival; △P < 0.05.
Gender		0.211 (0.781)		0.216 (0.695)
Male	2.2		8.0
Female	3.7		11.2
Age		0.362 (0.155)		0.363 (0.049△)
≥65	3.2		16.7
< 65	2.6		9.3
Smoking history		0.027△ (0.156)		0.054 (0.237)
Yes	2.2		7.1
No	3.5		11.0
Histology		0.095 (0.160)		0.291 (0.458)
Squamous cell carcinoma	1.9		6.9
Others	2.8		10.9
EGFR mutation status		0.891 (0.676)		0.992 (0.591)
Positive	2.1		9.9
Negative	2.6		10.8
Unknown	3.0		9.3
Interval between first- and fourth-line therapy		0.347 (0.502)		0.115 (0.238)
≥12 mo	2.8		11.4
< 12 mo	2.0		8.2
Performance status (Fourth-line)		0.661 (0.741)		0.381 (0.861)
0-1	2.8		11.0
≥2	2.6		8.7
Fourth-line therapy		0.221 (0.313)		0.012△ (0.007△)
Chemotherapy	2.7		11.7
Targeted therapy	2.6		7.1
Combined therapy	2.5		8.7
Continued therapy after fourth-line therapy
Yes			14.2	< 0.001△ (< 0.001△)
No			6.1