2.
RASSF1A启动子甲基化与临床病理因素之间的关系
Association between methylation of RASSF1A promoter and clinicopathologic variables
| Characteristic | NSCLC | Methylation rate (%) |
χ2 | P | ||
| Total | Methylated | Unmethylated | ||||
| NSCLC: non-small cell lung cancer. | ||||||
| Total | 150 | 58 | 92 | 38.7 | ||
| Age | - | > 0.05 | ||||
| ≤60 | 75 | 29 | 46 | 38.7 | ||
| > 60 | 75 | 29 | 46 | 38.7 | ||
| Sex | 1.400 | > 0.05 | ||||
| Male | 121 | 44 | 77 | 36.4 | ||
| Female | 29 | 14 | 15 | 48.3 | ||
| Histology | 3.408 | > 0.05 | ||||
| Adenocarcinoma | 40 | 18 | 22 | 45.0 | ||
| Squamous | 102 | 35 | 67 | 34.3 | ||
| Adenosquamous | 8 | 5 | 3 | 62.5 | ||
| Smoke index (pack-year) | 2.340 | > 0.05 | ||||
| 0 | 42 | 19 | 23 | 45.2 | ||
| < 20 | 20 | 5 | 15 | 25.0 | ||
| ≥20 | 88 | 34 | 54 | 38.6 | ||
| Age at starting smoking | 7.608 | 0.006 | ||||
| ≤20 | 30 | 17 | 13 | 56.7 | ||
| > 20 | 78 | 22 | 56 | 28.2 | ||
| Differentiated | 7.628 | 0.022 | ||||
| Poorly | 62 | 32 | 30 | 51.6 | ||
| Moderately | 58 | 18 | 40 | 31.0 | ||
| Well | 30 | 8 | 22 | 26.7 | ||
| TNM Stage | 5.817 | > 0.05 | ||||
| Ⅰ | 49 | 13 | 36 | 26.5 | ||
| Ⅱ | 32 | 12 | 20 | 37.5 | ||
| Ⅲa | 48 | 24 | 24 | 50.0 | ||
| Ⅲb-Ⅳ | 21 | 9 | 12 | 42.9 | ||