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采用PCR方法检测的EGFR突变对TKIs治疗的反应
Studies evaluating the predictive value of EGFR mutation and response to TKIs therapy
| Author | Cases | EGFR(+) | EGFR-mutant patients responsive to TKI therapy | EGFR(-) | EGFR-nonmutant patients responsive to TKI therapy | PPV | NPV |
| PPV: positive predictive value; NPV: negative predictive value. | |||||||
| Yoshida et al. (2009)[7] | 100 | 48 | 46 (95.8%) | 52 | 3 (5.8%) | 95.8% | 94.2% |
| Marcello et al. (2009)[8] | 63 | 11 | 9 (81.8%) | 52 | 5 (9.6%) | 81.8% | 90.4% |
| Miller et al. (2008) [9] | 81 | 18 | 15 (83.3%) | 63 | 4 (6.3%) | 83.3% | 93.7% |
| Hirsch et al. (2007) [10] | 204 | 43 | 17 (39.5%) | 113 | 8 (7.1%) | 39.5% | 92.9% |
| Sone et al. (2007) [11] | 59 | 17 | 10 (58.8%) | 42 | 6 (14.2%) | 58.8% | 85.8% |
| Ichihara et al. (2007)[12] | 98 | 38 | 25 (65.8%) | 60 | 0 | 65.8% | 100% |
| Sasaki et al. (2007) [13] | 54 | 26 | 19 (73.1%) | 28 | 6 (21.4%) | 73.1% | 78.5% |
| Pugh et al. (2007) [14] | 39 | 8 | 7 (87.5%) | 31 | 4 (12.9%) | 87.5% | 87.1% |
| Cappuzzo et al. (2007) [15] | 42 | 24 | 15 (62.5%) | 13 | 3 (23.1%) | 62.5% | 76.9% |