2.
采用FISH方法检测的EGFR扩增对TKIs治疗的反应
Studies evaluating the predictive value of EGFR amplification and polysomy and response to TKI therapy
| Author | Cases | EGFR(+) | EGFR-mutant patients responsive to TKI therapy | EGFR(-) | EGFR-nonmutant patients responsive to TKI therapy | PPV | NPV |
| Varella-Garcia et al. (2009)[21] | 44 | 29 | 19 (65.5%) | 15 | 4 (26.7%) | 65.5% | 73.3% |
| Marcello et al. (2009) [8] | 54 | 12 | 6 (50%) | 42 | 6(14.3%) | 50% | 85.7% |
| Hirsch et al. (2007) [10] | 204 | 59 | 20 (33.9%) | 124 | 7 (5.6%) | 33.9% | 94.4% |
| Sone et al. (2007) [11] | 59 | 26 | 8 (30.7%) | 28 | 6 (21.4%) | 30.7% | 78.6% |
| Sasaki et al. (2007)[13] | 27 | 12 | 7 (58.3%) | 15 | 7 (46.7%) | 58.3% | 53.3% |
| Pugh et al. (2007)[14] | 39 | 10 | 7 (70%) | 29 | 4 (13.8%) | 70% | 86.2% |
| Cappuzzo et al. (2007) [15] | 42 | 25 | 17 (68%) | 11 | 1 (9.1%) | 68% | 90.9% |