3.

采用IHC方法检测的EGFR过表达对TKIs治疗的反应

Studies evaluating the predictive value of EGFR overexpression and response to TKI therapy

Author	Cases	EGFR(+)	EGFR-mutant patients responsive to TKI therapy	EGFR(-)	EGFR-nonmutant patients responsive to TKI therapy	PPV	NPV
Marcello et al. (2009)[8]	59	45	11 (24.4%)	14	1 (7.1%)	24.4%	92.9%
Hirsch et al. (2007)[10]	204	121	27 (22.3%)	82	82 (4.9%)	22.3%	95.1%
Dziadziuszko et al. (2007) [29]	82	58	12 (20.7%)	20	4 (20%)	20.7%	80%
Cappuzzo et al. (2007)[15]	42	23	13 (56.5%)	11	4 (36.4%)	56.5%	63.6%