3.
足叶乙甙联合奥沙利铂和足叶乙甙联合顺铂的毒性反应（n=71)
Toxicities of etoposide plus oxaliplatin (EO) and etoposide plus cisplatin (EP) regimens (n=71)
| Toxicity | EO group (n=35) | EP group (n=36) | |||||||
| GradeⅠ | GradeⅡ | Grade Ⅲ | Grade Ⅳ | GradeⅠ | GradeⅡ | Grade Ⅲ | Grade Ⅳ | ||
| Leukopenia | 9 (25.7%) | 13 (37.1%) | 8 (22.9%) | 4 (11.1%) | 9 (25%) | 13 (36.1%) | 8 (22.2%) | 6 (16.7%) | |
| Thrombocytopenia | 14 (40.0%) | 8 (22.9%) | 5 (14.3%) | 2 (5.7%) | 11 (30.6%) | 6 (16.7%) | 4 (11.1%) | 2 (5.6%) | |
| Anemia | 11 (31.4%) | 7 (20%) | 1 (2.9%) | 0 | 16 (44.4%) | 7 (19.4%) | 3 (8.3%) | 0 | |
| Nausea/vomiting | 15 (42.9%) | 8 (22.9%) | 0 | 0 | 20 (55.6%) | 9 (26%) | 4 (11.1%) | 2 (5.6%) | |
| Impaired liver function | 4 (11.4%) | 0 | 0 | 0 | 2 (5.6%) | 1 (2.8%) | 0 | 0 | |
| Impaired renal function | 0 | 0 | 0 | 0 | 2 (5.6%) | 0 | 1 (2.8%) | 0 | |
| Neurocytoxicity | 17 (48.6%) | 9 (25.7%) | 0 | 0 | 3 (8.3%) | 1 (2.8%) | 0 | 0 | |
| Fatigue | 2 (5.7%) | 0 | 0 | 0 | 2 (5.6%) | 1 (2.8%) | 1 (2.8%) | 0 | |