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. 2018 May 30;20(5):e198. doi: 10.2196/jmir.9901

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©Sarah N Musy, Dietmar Ausserhofer, René Schwendimann, Hans Ulrich Rothen, Marie-Madlen Jeitziner, Anne WS Rutjes, Michael Simon. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 30.05.2018.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.

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Risk of bias and concerns regarding applicability assessments for diagnostic test accuracy studies (upper panel) and prevalence studies (lower panel). Judgments are expressed as “low,” “high,” or “unclear” risk or concern for each of the domains (ie, “patient selection,” “index test”). The percentages refer to the percentage of studies meeting the judgment low, high, or unclear risk of bias or concerns regarding applicability in each of the domains. Quality Assessment tool for Diagnostic Accuracy Studies-2 (QUADAS-2) was used for the two diagnostic test accuracy studies and an in-house developed tool was used to assess the 9 prevalence studies.