3.

毒副反应的meta分析

meta-analysis of the included trials on adverse effects

Outcome	Number of included studies	Aidi injection plus TP			TP			Heterogeneity		Analysis model	Statistical method	Effect estimate
		Events	Total		Events	Total		P	I2			RR (95%CI)	P
Hemotologic toxicity											Mantel-Haenazel
White blood cell	11 [11-21]	200	403		275	397		< 0.001	78%	Random effect		0.71 [0.57, 0.87]	0.001
Platelet	6[14, 17-21]	32	240		52	238		0.55	0%	Fixed effect		0.59 [0.40, 0.87]	0.008
Hemoglobin	3 [14, 17, 20]	57	130		57	126		0.28	22%			0.94 [0.76, 1.18]	0.61
Gastroenteric reaction
Nausea/vomiting	8[11-13, 15, 17-20]	123	291		164	289		0.02	57%	Random effect	Mantel-Haenazel	0.75 [0.58, 0.98]	0.03
Alopecia	2[11, 20]	26	84		26	76		0.46	0%	Fixed effect	Mantel-Haenazel	0.92 [0.63, 1.34]	0.66
Other toxicity										Fixed effect	Mantel-Haenazel
Liver	4[11, 18-20]	13	164		20	158		0.58	0%			0.63 [0.32, 1.23]	0.18
Kidney	4[11, 18-20]	4	164		10	158		0.99	0%			0.42 [0.12, 1.24]	0.12
Heart	1[13]	3	35		9	35		-	-			0.33 [0.10, 1.13]	0.08
Nerve	3[11, 19, 20]	29	124		32	116		0.46	0%			0.86 [0.56, 1.32]	0.50