1.

COX-2、c-Fos表达与非小细胞肺癌患者临床病理因素之间的关系

Association between expression of COX-2 and c-Fos and clinicopathologic characteristics of non-small cell lung cancer

Clinicopathologic characteristics(n=159)	n	Expression of COX-2		X2	P	Expression of c-Fos		X2	P
		Positive	Rate			Positive	Rate
Age				0.931	0.335			0.090	0.764
≤60	63	24	38.1%			28	44.4%
> 60	96	44	45.8%			45	46.9%
Gender				3.726	0.054			0.499	0.480
Male	111	53	47.7%			53	47.7%
Female	48	15	31.3%			20	41.7%
Smoking status				0.045	0.832			0.006	0.939
Never	67	28	41.8%			31	46.3%
Smoker	92	40	43.5%			42	45.7%
Differentiation				7.600	0.022			4.208	0.122
High	8	7	87.5 %			6	75.0%
Moderate	103	44	42.7%			49	47.6%
Low	48	17	35.4%			18	37.5%
Histologic type				7.723	0.005			3.634	0.057
Adenocarcinoma	74	23	31.1%			28	37.8%
Squamous cell carcinoma	85	45	52.9%			45	52.9%
Lymph node metastasis				0.800	0.371			0.234	0.628
No	73	34	39.5%			32	43.8%
Yes	86	34	46.6%			41	47.7%
TNM staging				0.018	0.895			0.089	0.297
Ⅰ + Ⅱ	109	47	43.1%			47	43.1%
Ⅲ	50	21	42.0%			26	52.0%