1.

EGFR和COX-2的表达及与临床病理学参数的关系

Associations between expression of EGFR and COX-2 and clinicopathologic parameters

Variables and Categories	n	Expression of EGFR		χ2	P	Expression of COX-2		χ2	P
		Positive	Positive rate			Positive	Positive rate
*non-small cell lung cancer vs small cell lung caner.
Samples				10.413	0.015			11.881	0.008
Primary lung cancer	89	53	59.60%			47	52.80%
Premalignant lesion	12	5	41.70%			5	41.70%
Metastatic lung cancer in lymph node	12	8	66.70%			8	66.70%
Normal lung tissue	10	1	10.00%			0	0
Sex				0.203	0.653			0.035	0.851
Male	67	39	58.20%			35	52.20%
Female	22	14	63.60%			12	54.50%
Age				0.037	0.847			0.191	0.662
> 60	53	32	60.40%			29	54.70%
< 60	36	21	58.30%			18	50.00%
Gross type				0.726	0.394			15.777	< 0.001
Peripheral type	59	37	62.70%			40	67.80%
Central type	30	16	53.30%			7	23.30%
Histologic type				12.945	0.005			18.896	< 0.001
Adenocarcinoma	35	23	65.70%			21	60.00%
Squamous cell carcinoma	33	20	60.60%			18	54.50%
Large cell lung cancer	9	8	88.90%			8	88.90%
Small cell lung caner	12	2	16.70%			0	0
Non-small cell lung cancer	77	51	66.20%	- 0.003*	47	61.00%	15.521	< 0.001*
Differentiation				0.037	0.847			0.001	0.996
High-moderate	53	32	60.40%			28	52.80%
Low-undifferentiation	36	21	58.30%			19	52.80%
Stage				8.058	0.005			4.041	0.044
Ⅰ+Ⅱ	56	27	48.20%			25	44.60%
Ⅲ+Ⅳ	33	26	78.80%			22	66.70%
Lymph node metastasis				10.325	0.001			3.927	0.048
Present	48	36	75%			30	62.50%
Absent	41	17	41.50%			16	41.50%