3.
按NCI CTCAE 3.0版的拓扑替康维持/巩固及挽救治疗的3/4级毒性
Grade 3/4 toxicities of topotecan in maintenance/consolidation and salvage chemotherapy
| Toxicities | Maintenance/Consolidation chemotherapy (n=29) | Salvage chemotherapy (n=24) | P |
| Hematologic toxicities | |||
| Leukopenia | 0.48 | ||
| Grade 3 | 4(13.8%) | 2 (8.3%) | |
| Grade 4 | 2 (6.9%) | 1 (4.2%) | |
| Thrombocytopenia | 0.23 | ||
| Grade 3 | 6 (20.7%) | 9 (37.5%) | |
| Grade 4 | 0 | 0 | |
| Anemia | 0.27 | ||
| Grade 3 | 1 (3.4%) | 5 (20.8%) | |
| Grade 4 | 2 (6.9%) | 1 (4.2%) | |
| Nonhematologic toxicities (Grade 3/4) | |||
| Nausea | 3 (10.3%) | 0 | 0.24 |
| Vomiting | 3 (10.3%) | 0 | 0.24 |
| Anorexia | 4(13.8%) | 0 | 0.12 |
| Diarrhea | 1 (3.4%) | 1 (4.1%) | 0.89 |
| Alopecia | 2 (6.8%) | 2 (8.3%) | 0.65 |