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非小细胞肺癌患者血清IL-8、MMP-9表达水平与临床病理特征的关系
The relationship between serum IL-8 and MMP-9 and the clinicopathological characteristics
| Variables | n | IL-8 (pg/mL) | P | MMP-9 (ng/mL) | P | ||
| Median | Quartile | Median | Quartile | ||||
| Group | < 0.001 | < 0.001 | |||||
| Health | 40 | 16.55 | 11.83-35.18 | 29.41 | 18.81-56.11 | ||
| Benign disease | 40 | 27.20 | 13.43-541.35 | 51.98 | 20.29-87.52 | ||
| Non-small cell lung cancer | 141 | 138.10 | 42.55-327.95 | 88.49 | 39.19-145.64 | ||
| Pathologic stage | < 0.001 | < 0.001 | |||||
| Stage Ⅰ | 38 | 33.10 | 19.75-78.10 | 41.86 | 22.95-113.83 | ||
| Stage Ⅱ | 21 | 110.60 | 21.15-418.10 | 27.16 | 19.19-131.46 | ||
| Stage Ⅲ | 53 | 163.00 | 102.05-322.80 | 89.51 | 59.10-122.96 | ||
| Stage Ⅳ | 29 | 331.30 | 198.90-581.20 | 149.70 | 109.07-240.07 | ||
| Tumor status | 0.080 | 0.006 | |||||
| T1 | 17 | 55.60 | 21.95-223.15 | 40.63 | 18.75-103.98 | ||
| T2 | 54 | 89.55 | 31.38-227.80 | 60.65 | 28.88-120.42 | ||
| T3 | 17 | 110.60 | 19.05-274.10 | 68.74 | 23.71-112.29 | ||
| T4 | 7 | 370.70 | 157.00-662.20 | 240.06 | 103.74-351.37 | ||
| Lymph node status | < 0.001 | 0.002 | |||||
| N0 | 51 | 33.10 | 17.90-91.30 | 40.63 | 19.02-113.55 | ||
| N1 | 12 | 328.75 | 84.75-647.13 | 149.68 | 39.60-211.77 | ||
| N2 | 32 | 152.05 | 111.85-315.40 | 88.36 | 58.04-115.39 | ||
| Distant metastasis | 0.006 | 0.001 | |||||
| Present | 89 | 91.30 | 23.20-222.60 | 59.28 | 25.00-116.58 | ||
| Absent | 6 | 395.95 | 303.35-486.30 | 240.07 | 129.84-316.95 | ||
| Tumor size | 0.071 | 0.071 | |||||
| ≤3 cm | 34 | 56.45 | 19.75-165.20 | 40.10 | 19.63-106.19 | ||
| > 3 cm | 61 | 114.90 | 34.55-320.55 | 77.13 | 41.81-128.45 | ||
| Histology | 0.229 | 0.685 | |||||
| Adenocarcinoma | 50 | 98.20 | 22.08-226.43 | 65.81 | 26.94-116.54 | ||
| Squamous cell carcinoma | 40 | 97.70 | 34.08-571.50 | 60.71 | 26.29-130.06 | ||
| Differentiation | 0.611 | 0.395 | |||||
| Poorly | 9 | 94.70 | 24.60-106.55 | 56.98 | 21.77-85.97 | ||
| Moderately | 76 | 110.90 | 27.48-308.73 | 71.35 | 25.54-135.03 | ||
| Well | 10 | 99.95 | 21.93-850.00 | 44.14 | 27.37-132.35 | ||
| Location | 0.672 | 0.757 | |||||
| Central | 37 | 96.10 | 22.60-267.10 | 75.19 | 29.96-116.58 | ||
| Peripheral | 58 | 105.25 | 31.23-314.20 | 59.10 | 23.38-136.74 | ||
| Gender | 0.929 | 0.164 | |||||
| Male | 79 | 110.60 | 23.00-304.30 | 68.74 | 37.50-119.83 | ||
| Female | 16 | 88.65 | 27.98-287.40 | 27.59 | 15.52-141.22 | ||
| Age (years) | 0.926 | 0.465 | |||||
| ≤60 | 44 | 93.00 | 22.20-308.73 | 55.43 | 21.88-118.26 | ||
| > 60 | 51 | 105.10 | 26.20-226.20 | 77.13 | 30.17-136.14 | ||
| Smoking | 0.154 | 0.399 | |||||
| Non-smoker | 38 | 82.55 | 22.60-219.13 | 55.04 | 20.80-124.57 | ||
| Smoker | 57 | 114.90 | 25.90-328.75 | 73.95 | 33.62-122.53 | ||