4.

IL-8、MMP-9作为肿瘤标志物对非小细胞肺癌病情进展的评价效能

Comparison of IL-8, MMP-9 performances as possible indicators of cancer presence and dissemination

Marker category	AUC (95%CI); (AUC=0.5)	P	Optimal cut-off	Sensitivity and specificity	Youden's index	Likelihood ratios (PV+/PV-)
ROC curve: receiver operating characteristics curve; CI: confidence intervals.
NSCLC presence
IL-8	0.588 (0.481-0.695)	0.123	86.35 pg/mL	21.1%, 76.2%	-0.027	0.296/0.670
MMP-9	0.555 (0.439-0.671)	0.333	76.36 ng/mL	31.6%, 77.5%	0.091	0.400/0.705
Cancer disseminaton
IL-8	0.811 (0.719-0.904)	< 0.001	110.90 pg/mL	76.6%, 79.2%	0.558	0.783/0.776
MMP-9	0.700 (0.594-0.806)	0.001	79.77 pg/mL	63.8%, 72.9%	0.367	0.698/0.673
Distant metastasis
IL-8	0.763 (0.681-0.846)	< 0.001	313.20 pg/mL	62.1%, 77.7%	0.398	0.419/0.888
MMP-9	0.817 (0.740-0.893)	< 0.001	126.19 pg/mL	69.0%, 79.5%	0.485	0.465/0.908