1.

荷瘤小鼠经不同处理后肿瘤体积变化（n=8, Mean±SD）

Variation of tumor size of A549 lung carcinoma tumor (n=8, Mean±SD)

Day1	Group 1: PC3.1 (+)	Group 2: Cy-HN	Group 3: Sc-HN	Group 4: M-HN	Group 5: Physiological saline	P2	Post-hoc test3
SD=standard deviation; Cy-HN: cytoplasmic HN; Sc: secreted HN; M: membrane-anchored HN; PC3.1(+): pcDNA3.1(+); NA=not available; 1 Linear mixed model was implemented to examine the differences between the time-points studied; 2 One-way ANOVA was performed; 3 LSD test or Dunnett’s T3 test was used; * Significantly different among all groups, P < 0.05; Different letters meaned significant differences between various time-points, P < 0.05.
6	22.8±2.4 a	20.9±3.6 a	21.4±2.1 a	20.7±1.6 a	23.0±3.5 a	0.336	NA
9	27.0±3.5 b	23.9±1.6 b	23.8±1.7 b	22.4±0.8 b	25.2±3.4 b	0.007*	G1 < G4
12	32.4±0.2 c	26.1±1.0 c	26.6±2.0 c	25.1±0.9 c	31.8±0.3 c	< 0.001*	G2=G3=G4 < G5 < G1
15	32.3±1.8 c	27.3±0.5 c	27.0±1.2 c	25.9±2.1 c	33.4±1.7 c	< 0.001*	G2=G3=G4 < G1=G5
18	36.9±0.7 d	31.8±0.8 d	32.0±3.9 d	29.4±1.4 d	36.5±1.2 d	< 0.001*	G4 < G2 < G3 < G1=G5
21	42.0±1.6 e	34.0±0.8 e	34.8±1.3 e	32.7±0.3 e	44.2±0.1 e	< 0.001*	G4 < G2=G3 < G1 < G5