1.

gp96、CTLA-4和CD8在原发性肺癌中的表达与临床病理参数的关系

Associations between the expressions of gp96, CTLA-4 and CD8 in lung cancer and clinicopathologic paramenters

Group	n	gp96				CTLA-4				CD8
		Positive rate (%)	X2	P		Positive rate (%)	X2	P		Positive rate (%)	X2	P
Gender			10.215	0.001			0.553	0.457			0.101	0.751
Male	67	94.00				88.06				55.22
Famale	22	68.20				81.81				19.40
Age			2.801	0.094			3.958	0.047			0.597	0.440
≥60	53	92.50				92.45				52.83
< 60	36	80.60				77.78				61.11
Gross type		0.040	0.842			3.393	0.531			2.022	0.155
Peripheral type	59	88.10				88.14				50.85
Central type	30	86.70				83.33				66.67
Histological type
Non-small cell lung caner	77	81.81	1.257	0.739		87.01	1.259	0.739		61.03	6.959	0.073
Adenocarcinoma	35	82.86				85.71				68.57
Squamous cell carcinoma	33	90.90				90.91				54.55
Large cell carcinoma	9	89.00				77.78				55.56
Small cell lung caner	12	92.00				83.33				25.00
Differentiation		5.124	0.024			5.939	0.015			1.970	0.160
High-moderate	53	81.13				79.24				62.26
Low-undifferentiation	36	97.22				97.22				47.22
Stage			4.214	0.040			0.867	0.352			4.031	0.045
Ⅰ+Ⅱ	56	82.14				83.93				64.28
Ⅲ+Ⅳ	33	96.97				90.91				42.42
Lymph node metastasis			1.559	0.212			0.840	0.359			0.760	0.383
Present	48	91.67				89.58				60.42
Absent	41	82.93				82.93				51.22