5.

66例患者治疗平均成本对比分析(包括每个周期的靶向治疗药物费用, 治疗药物不良反应的药物以及相应住院费用)

The average cost analysis of 66 patients (including the cost of drugs, the treatment of adverse effects, and cost of hospitalization)

Outcome/1 cycle	Gefitinib (RMB)	Erlotinib (RMB)
Guangzhou medical insurance fixed payment procedure was started from February 2010, the patients who enrolled before were excluded from the analysis of cost-effectiveness with medical insurance. * Guangzhou medical insurance can cover 15, 000 RMB at most for patients per month.
Cost of drugs	16, 351	19, 731
Cost of laboratory and imaging test	1, 288	1, 352
Cost of adverse event
Rash	77	236
Diarrhea	11	39
Liver damage	35	15
Cost of hospitalization	265	427
Hypothetical PFS (months)	17.5	13.0
Without medical insurance
Total costs	315, 472	283, 400
Cost-effectiveness ratio	18, 027	21, 800
ICER per PF-LYS	Referent	1.21
With medical insurance*
Medical insurance *	-262, 500	-195, 000
Total costs	52, 972	88, 400
Cost-effectiveness ratio	3, 027	6, 800
ICER per PF-LYS	Referent	2.25