1.
云锡矿工队列人群特征及肺癌死亡分布
Characteristics and lung cancer mortality of Yunnan tin miner cohort
| Characteristics | Participants No. | Person-year | Case No. | Death rate | Death rate ratio (95%CI) |
| Age (yr) | |||||
| < 60 | 6, 169 | 49, 707.9 | 107 | 215.3 | 1.00 |
| 60-69 | 2, 494 | 19, 699.0 | 256 | 1, 299.6 | 6.01 (4.80-7.53) |
| ≥70 | 632 | 4, 139.2 | 80 | 1, 932.7 | 9.36 (7.00-12.51) |
| Gender | |||||
| Female | 599 | 4, 485.6 | 2 | 44.6 | 1.00 |
| Male | 8, 696 | 69, 060.5 | 441 | 638.6 | 13.85 (3.45-55.58) |
| Education level | |||||
| No | 2, 206 | 17, 390.1 | 222 | 1, 276.6 | 1.00 |
| ≤6 y | 4, 457 | 36, 519.1 | 198 | 542.2 | 0.42 (0.35-0.51) |
| ＞6 y | 2, 632 | 19, 636.9 | 23 | 117.1 | 0.09 (0.06-015) |
| Smoking status | |||||
| Never | 1, 451 | 11, 148.7 | 19 | 170.4 | 1.00 |
| Former | 894 | 6, 918.0 | 53 | 766.1 | 3.85 (2.42-6.11) |
| Current | 6, 950 | 55, 479.4 | 371 | 668.7 | 4.40 (2.60-7.43) |
| Pack-years of smoking | |||||
| Q1 (0) | 1, 451 | 11, 182.1 | 19 | 169.9 | 1.00 |
| Q2 (1-583) | 1, 968 | 15, 565.1 | 117 | 751.7 | 4.33 (2.66-7.03) |
| Q3 (584-1, 022) | 1, 961 | 15, 674.1 | 129 | 823.0 | 4.74 (2.93-7.67) |
| Q4 (1, 023-1, 540) | 2, 006 | 16, 228.8 | 103 | 634.7 | 3.65 (2.24-5.96) |
| Q5 (> 1, 540) | 1, 909 | 14, 896.0 | 75 | 503.5 | 2.93 (1.77-4.85) |
| Cumulative arsenic exposure (IAEM) | |||||
| Q1 (0-1, 455) | 2, 440 | 18, 444.7 | 13 | 70.5 | 1.00 |
| Q2 (1, 456-7, 102) | 2, 284 | 19, 394.7 | 75 | 386.7 | 5.27 (2.92-9.50) |
| Q3 (7, 102-17, 435) | 2, 286 | 18, 180.6 | 242 | 1, 331.1 | 18.41 (10.54-32.17) |
| Q4 (≥17, 435) | 2, 285 | 17, 526.1 | 113 | 644.8 | 9.08 (5.11-16.12) |
| Previous asthma | |||||
| No | 8, 620 | 68, 337.0 | 377 | 551.7 | 1.00 |
| Yes | 675 | 5, 209.1 | 66 | 1, 267.0 | 2.29 (1.76-2.97) |
| Previous chronic bronchitis | |||||
| No | 6, 866 | 54, 226.7 | 244 | 450.0 | 1.00 |
| Yes | 2, 429 | 19, 319.4 | 199 | 1, 030.1 | 2.26 (1.88-2.73) |
| Previous silicosis | |||||
| No | 8, 841 | 70, 125.4 | 389 | 554.7 | 1.00 |
| Yes | 454 | 3, 420.7 | 54 | 1, 578.6 | 2.86 (2.15-3.80) |
| Previous tuberculosis | |||||
| No | 9, 031 | 71, 435.0 | 425 | 594.9 | 1.00 |
| Yes | 264 | 2, 111.1 | 18 | 852.6 | 1.14 (0.88-2.26) |
| Cumulative radon exposure | |||||
| 0 | 1, 846 | 14, 428.3 | 17 | 117.8 | 1.00 |
| Q1 (0-95.82) | 1, 865 | 14, 102.4 | 33 | 234.0 | 2.00 (1.12-3.59) |
| Q2 (95.82-148.44) | 1, 860 | 15, 079.6 | 49 | 324.9 | 2.72 (1.57-4.73) |
| Q3 (148.44-295.84) | 1, 862 | 15, 276.5 | 129 | 844.4 | 7.03 (4.24-11.66) |
| Q4 (≥295.84) | 1, 862 | 14, 659.3 | 215 | 1, 466.6 | 12.30 (7.51-20.17) |