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成纤维生长因子受体的结构及其下游信号通路

The structure and downstream signaling pathways of fibroblast growth factor receptor. PIP2: phosphatidylinosital-4, 5-biphosphate; PLCγ: phospholipase Cγ; IP3: inositol triphosphate; FSR2α: FGFR substrate 2α; GRB2: growth factor receptor bound 2; GAB1: Grb2-associated binder; SOS: son of sevenless; MAPK: mitogen-activated protein kinases; STAT: signal transducers and activators of transcription; PI3K: phosphatidylinositol 3-hydroxy kinase; Akt: serine-threonine protein kinase.