1.

患者临床特征

Clinical characteristics of included patients

Characteristics	Irinotecan+Nedaplantin (n=34)	Irinotecan+Cisplantin (n=20)
Age (yr)
< 65	30 (88.2%)	17 (85.0%)
≥65	4 (11.8%)	3 (15.0%)
Gender
Male	28 (82.4%)	16 (80.0%)
Female	6 (17.6%)	4 (20.0%)
Stage
Limited	12 (35.3%)	5 (25.0%)
Extensive	22 (64.7%)	15 (75.0%)
Lung metastasis
Yes	9 (26.5%)	5 (25.0%)
No	25 (73.5%)	15 (75.0%)
Bone metastasis
Yes	9 (26.5%)	7 (35.0%)
No	25 (73.5%)	13 (65.0%)
Liver metastasis
Yes	7 (20.6%)	3 (15.0%)
No	27 (79.4%)	17 (85.0%)
Brain metastasis
Yes	15 (44.1%)	6 (30.0%)
No	19 (55.9%)	14 (70.0%)
Treatment-interval
< 90 d	12 (35.3%)	6 (30.0%)
90 d-180 d	18 (52.9%)	9 (45.0%)
> 180 d	4 (11.8%)	5 (25.0%)